- Infographic: partner EFIC has created an infographic to help you quickly grasp what IMI-PainCare is all about.
- Handout IMI-PainCare: This pdf is a brochure with more detailed information about the project
- IMI-PainCare flyer: This pdf encodes a flyer with some overview information about the project
Scientific publications
2023
The Unmet Needs for Studying Chronic Pelvic/Visceral Pain Using Animal Models
Neto AC, et al.; Biomedicines 2023, 11(3), 696
https://www.mdpi.com/2227-9059/11/3/696
Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis
Tejada, MA et al. International journal of molecular sciences vol. 24,3 2422. 26 Jan. 2023
https://www.mdpi.com/1422-0067/24/3/2422
Patient Reported Outcome Measures in Chronic Neuropathic Pain Clinical Trials − A Systematic Literature Review
Sachau et al.; The Journal of Pain, 24(1): 38
https://www.jpain.org/action/showPdf?pii=S1526-5900%2822%2900393-5
2022
RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity
Leone et al.; Trials (2022) 23:739
https://doi.org/10.1186/s13063-022-06431-5
Review: Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development
van Nil H et al.; Int. J. Mol. Sci. 23:8295
https://doi.org/10.3390/ijms23158295
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain
Tejada et al.; Biomedicines 10:501
https://doi.org/10.3390/biomedicines10020501
IMI2 - PainCare - BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)
Nochi et al.; Trials 23:163
https://doi.org/10.1186/s13063-022-06087-1
Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain
Gierthmühlen et al.; PAIN 163:1378–1387
https://doi.org/10.1097/j.pain.0000000000002501
Leone et al.; Trials (2022) 23:739
https://doi.org/10.1186/s13063-022-06431-5
Review: Pharmacological Probes to Validate Biomarkers for Analgesic Drug Development
van Nil H et al.; Int. J. Mol. Sci. 23:8295
https://doi.org/10.3390/ijms23158295
Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain
Tejada et al.; Biomedicines 10:501
https://doi.org/10.3390/biomedicines10020501
IMI2 - PainCare - BioPain-RCT1: study protocol for a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by peripheral nerve excitability testing (NET)
Nochi et al.; Trials 23:163
https://doi.org/10.1186/s13063-022-06087-1
Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain
Gierthmühlen et al.; PAIN 163:1378–1387
https://doi.org/10.1097/j.pain.0000000000002501
2021
The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation suggesting an involvement of spinal wide dynamic range neurons
Pietro et al.; Neurophysiologie Clinique 51_517
https://doi.org/10.1016/j.neucli.2021.09.001
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.
Di Lionardo et al.; Scientific Reports 11:20838
https://doi.org/10.1038/s41598-021-00313-7
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex
Leone et al.; Clinical Neurophysiology 132:2989
https://doi.org/10.1016/j.clinph.2021.08.018
Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain
Nunez-Badinez et al.; PAIN 2+3(9):2349
https://dx.doi.org/10.1097/j.pain.0000000000002248
Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery
Harikouk et al.; Reg Anesth Pain Med 46:251–257.
https://doi.org/10.1136/rapm-2020-102040
Developing consensus on core outcome domains for assessing effectiveness in perioperative pain management: results of the PROMPT/IMI-PainCare Delphi Meeting
Pogatzki-Zahn et al. PAIN 162(11):2717
https://doi.org/10.1097/j.pain.0000000000002254
BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)
Mouraux et al.; Trials 22:404
https://doi.org/10.1186/s13063-021-05272-y
Human surrogate models of central sensitization: A critical review and practical guide
Quesada et al.; Eur J Pain 25(7):1389
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360051/pdf/EJP-25-1389.pdf
Pietro et al.; Neurophysiologie Clinique 51_517
https://doi.org/10.1016/j.neucli.2021.09.001
Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.
Di Lionardo et al.; Scientific Reports 11:20838
https://doi.org/10.1038/s41598-021-00313-7
How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex
Leone et al.; Clinical Neurophysiology 132:2989
https://doi.org/10.1016/j.clinph.2021.08.018
Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain
Nunez-Badinez et al.; PAIN 2+3(9):2349
https://dx.doi.org/10.1097/j.pain.0000000000002248
Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery
Harikouk et al.; Reg Anesth Pain Med 46:251–257.
https://doi.org/10.1136/rapm-2020-102040
Developing consensus on core outcome domains for assessing effectiveness in perioperative pain management: results of the PROMPT/IMI-PainCare Delphi Meeting
Pogatzki-Zahn et al. PAIN 162(11):2717
https://doi.org/10.1097/j.pain.0000000000002254
BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG)
Mouraux et al.; Trials 22:404
https://doi.org/10.1186/s13063-021-05272-y
Human surrogate models of central sensitization: A critical review and practical guide
Quesada et al.; Eur J Pain 25(7):1389
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360051/pdf/EJP-25-1389.pdf
2020
Urinary bladder sigma-1 receptors: A new target for cystitis treatment
González-Cano et al.; Pharmacological Research 155:104724
https://doi.org/10.1016/j.phrs.2020.104724
Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis
Kaiser et al.; Trials, 21:773
https://doi.org/10.1186/s13063-020-04665-9
González-Cano et al.; Pharmacological Research 155:104724
https://doi.org/10.1016/j.phrs.2020.104724
Developing consensus on core outcome domains and measurement instruments for assessing effectiveness in perioperative pain management after sternotomy, breast cancer surgery, total knee arthroplasty, and surgery related to endometriosis
Kaiser et al.; Trials, 21:773
https://doi.org/10.1186/s13063-020-04665-9
2019
Effect of Water Avoidance Stress on serum and urinary NGF levels in rats: diagnostic and therapeutic implications for BPS/IC patients
Dias et al.; Scientific Reports 9:14113, 1
https://doi.org/10.1038/s41598-019-50576-4
PT221 - Bladder pain induced by chronic stress is mediated by a systemic increase of nerve growth factor involving the activation of adrenoceptors
Dias et al.; Eur Urol Suppl 18(1), e1967
https://doi.org/10.1016/S1569-9056(19)31425-3
Dias et al.; Scientific Reports 9:14113, 1
https://doi.org/10.1038/s41598-019-50576-4
PT221 - Bladder pain induced by chronic stress is mediated by a systemic increase of nerve growth factor involving the activation of adrenoceptors
Dias et al.; Eur Urol Suppl 18(1), e1967
https://doi.org/10.1016/S1569-9056(19)31425-3
2018
IMI-PAINCARE, BIOPAIN: validation chez l’homme de nouveaux biomarqueurs fonctionnels pour le éveloppement pharmacologique de traitements de la douleur
Stouffs et al.
Douleur et analgésie, Volume 31, Numéro 4, Décembre 2018
https://doi.org/10.3166/dea-2018-0041
Stouffs et al.
Douleur et analgésie, Volume 31, Numéro 4, Décembre 2018
https://doi.org/10.3166/dea-2018-0041
Posters
PROMPT
BIOPAIN
TRiPP
- 01_PR Setting up and implementing a multiple languages, multi-center PROMs surve (Claudia Weinmann)
- 02_PR Including the patient’s perspective - A systematic literature review of Patient Reported Outcome Measures in chronic neuropathic pain clinical trials (Juliane Sachau, Manon Sendel, Marie Péchard, Kathrin Schnabel, Iris Schmieg, Terkia Medkour, Laurent Ecochard, Markus Woischnik, Hiltrud Liedgens, Esther Pogatzki-Zahn, Ralf Baron, Didier Bouhassira) (IASP22)
- 03_PR Objectively tracked activity is not correlated with patient-reported pain treatment outcomes one week after surgery(Marcus Komann, Claudia Weinmann, Winfried Meißner)
BIOPAIN
- 04_BP Modulation of Laser Evoked Potentials by Lacosamide, Pregabalin & Tapentadol in Awake Rats (Anthony Blockeel, Anna Sales, Sonya Chapman, Kimberley Jackson, Nicolás Marco-Ariño, Iñaki Trocóniz, Josep-Maria Cendros, Jose Miguel Vela, Anthony Pickering, Andrea Truini, Andre Mouraux, Rolf-Detlef Treede & Keith Phillips)
- 05_BP Characterisation of the neural correlates of central sensitisation induced by the high frequency stimulation (HFS) model in healthy humans using functional magnetic resonance imaging (fMRI) (Sophie Clarke, Vishvarani Wanigasekera, Richard Rogers, Francesca Fardo, Hossein Pia, Zahra Nochi, Nicolas Macian, Vincent Leray, Nanna Brix Finnerup, Gisèle Pickering, André Mouraux, Andrea Truini, Rolf-Detlef Treede and Irene Tracey)
- 06_BP Perception threshold tracking (PTT) - A novel method to assess small fiber function (Hossein Pia, Zahra Nochi, Bernhard Pelz, Marcus Goetz, Jan Hoeink, Rolf-Detlef Treede, Tony Blockeel, Keith Phillips, Nanna Brix Finnerup, Hatice Tankisi)
- 07_BP Does peak alpha-frequency of the resting EEG predict the susceptibility to develop secondary mechanical hyperalgesia? (L. Lebrun, C. Lenoir, E. N. van den Broeke, A. Mouraux)
- 08_BP Investigating the effect of negative expectations on pain and secondary hyperalgesia (S.Gousset, T. Cayrol, M. Papleux, A. Mouraux, E. N. van den Broeke)
TRiPP
- 09_TR Analysis of Rat Ultrasonic Vocalizations in a Preclinical Model for Inflammatory Pain (Paulina Nunez-Badinez, Bianca De Leo, Alexis Laux-Biehlmann, Katy vincent, Jens Nagel)
- 10_TR Exploring pelvic pain and quality of life profiles in the Translational Research in Pelvic Pain (TRiPP) cohort (Lysia Demetriou, Michal Krassowski, Pedro Abreu Mendes, Kurtis Garbutt, Allison Vitonis, Elizabeth Wilkins, Lydia Coxon, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Claire E Lunde, Jane Meijlink, Danielle Perro, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent)
- 11_TR What drinking water tells us about bladder sensitivity in Chronic Pelvic Pain (Lydia Coxon, Emily Tan, Danielle Perro, Claire Lunde, Joana Ferreira Gomes, Ana Charrua Cordeiro, Pedro Abreu Mendes, Jane Meijlink, Anja Hoffman, Judy Birch, Lone Humnelshoj, Qasim Aziz, Lars Arendt-Nielsen, Esther Pogatzki-Zahn Jan Vollert, Michal Krassowski, Emma Evans, Rolf-Detlef Treede, Lysimachi Demetriou, Stacey Missmer, Andrew Horne, Christine Sieberg, Fransisco Cruz, Jens Nagel, Katy Vincent)
- 12_TR Is conditioned pain modulation (CPM) a useful paradigm in women? A TRiPP study exploring CPM in pain-free women and those living with chronic pelvic pain (Danielle Perro, Lydia Coxon, Claire Lunde, Joana Ferreira Gomes, Ana Charrua, Pedro Abreu Mendes, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Lysia Demetriou, Kurtis Garbutt, Andrew Horne, Anja Hoffman, Lone Hummelshoj, Michal Krassowski, Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Allison Vitonis, Jan Vollert, Christian Becker, Franscisco Cruz, Christine Sieberg, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent, on behalf of the TRiPP Consortium)
- 13_TR Understanding Fatigue in Chronic Pelvic Pain patients: a Translational Research in Pelvic Pain (TRiPP) study (Lysia Demetriou, Lydia Coxon, Danielle Perro, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Michal Krassowski, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne , Anja Hoffman, Lone Hummelshoj, , Jane Meijlink, Danielle Perro, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent )
- 14_TR Have you ever had a flare of your symptoms? Clinically important findings from under-explored FLARES in Chronic Pelvic Pain (Lydia Coxon, Celia Lugt, Danielle Perro, Claire Lunde, Joana Ferreira Gomes, Ana Charrua Cordeiro, Pedro Abreu Mendes, Judy Birch, Jane Meijlink, Lone Humnelshoj, Anja Hoffmann, Qasim Aziz, Lars Arendt-Nielsen, Esther Pogatzki-Zahn, Jan Vollert, Michal Krassowski, Emma Evans, Rolf-Detlef Treede, Lysimachi Demetriou, Stacey Missmer, Andrew Horne, Christine Sieberg, Fransisco Cruz, Jens Nagel, Katy Vincent)
- 15_TR Widespread pain is associated with poor psychological health, sleep quality, fatigue, and pain catastrophizing in women with chronic pelvic pain: A TRiPP study (Danielle Perro, Lysia Demetriou, Lydia Coxon, Michal Krassowski, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne , Anja Hoffman, Lone Hummelshoj, Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent, on behalf of the TRiPP Consortium)
- 16_TR The relationship between pain experience and personality factors in women living with chronic pelvic pain (Emma Evans, Lysia Demetriou, Lydia Coxon, Danielle Perro, Pedro Abreu Mendes, Claire E Lunde, Kurtis Garbutt, Michal Krassowski, Allison Vitonis, Lars Arendt-Nielsen, Qasim Aziz, Judy Birch, Andrew Horne, Anja Hoffman, Lone Hummelshoj, , Jane Meijlink, Esther Pogatzki-Zahn, Christine Sieberg, Rolf-Detlef Treede, Christian Becker, Franscisco Cruz, Stacey Missmer, Krina Zondervan, Jens Nagel, Katy Vincent)
- 17_TR Multi-Center Analysis of Spontaneous Behaviour in Pre-Clinical Models of ENDO using HCA systems (P. Nunez-Badinez et al)
- 18_TR BPS/IC-related to better reproduce urinary bladder changes and pain (Santos-Pereira M, Santos-Leite L, Serrão P, Cruz F, Charrua A)
